200909020641香港一例H1N1運用血漿療法失敗

利用恢復病者血漿治療曾是SARS時的很好及最後的治療方式,也成功治療許多SARS病例,但香港最近卻運用N1N1卻沒有成功。

下文中也提及吸煙者似乎較容易受H1N1的侵害.

Victim dies after blood fix fails

Hong Kong's human swine flu (H1N1) death toll climbed to five yesterday when last-ditch efforts to save a 43-year-old woman by giving her the blood serum of a recovered patient failed.

Mary Ann Benitez

Monday, August 31, 2009

Hong Kong's human swine flu (H1N1) death toll climbed to five yesterday when last-ditch efforts to save a 43-year-old woman by giving her the blood serum of a recovered patient failed.

It is thought to be the first time that the blood - or convalescent - serum of someone who survived swine flu has been used on a patient in Hong Kong.

In late July, doctors tried in vain to save a critically ill woman using an artificial lung machine. The latest victim was a "chronic smoker" who did not have any other underlying disease.

She developed flu symptoms on August 23 and went to a designated flu clinic run by the Hospital Authority the following day.

Last Wednesday, she went to Tuen Mun Hospital's accident and emergency department and was admitted to the isolation ward. The test for pandemic H1N1 flu returned positive hours later.

It was only after confirmation that the woman was given the antivirals Tamiflu and Relenza and antibiotics. Her condition worsened quickly and she was transferred to intensive care later that day and put on a ventilator.

"Her condition continued to deteriorate and convalescent serum was given on August 29. She died at 12.17am," the hospital said yesterday.

So far, there have been 51 severe cases of pandemic H1N1 reported in Hong Kong, with five deaths. A total of 21 critically ill patients have made a full recovery. Eleven remain critically ill in hospitals, including a new case involving an 18-year-old woman at Prince of Wales Hospital.

David Hui Sui-cheong, a specialist in respiratory medicine at Chinese University, said the Tuen Mun Hospital case could be the first time that convalescent serum had been tried to save a swine flu patient here. At the height of the SARS crisis in 2003 around 100 patients received convalescent serum. "We had very good results because convalescent serum contains the neutralizing antibodies and so it is a very good adjunct therapy," Hui said.

He added that smokers were particularly at risk of severe symptoms because the pandemic flu virus infects the lungs directly.

"If doctors have a strong suspicion of a case of severe human swine flu, they should use Tamiflu straight away. If the patient has a risk factor or severe disease, you do not wait for the [confirmatory test] results," Hui said.

As of yesterday, the number of confirmed cases stood at 11,578, with 331 new cases comprising 176 males and 155 females, aged between five months and 84 years.

On Saturday, the World Health Organization said: "Clinicians around the world are reporting a very severe form of the disease, also in young and otherwise healthy people, which is rarely seen during seasonal influenza infections."

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