Treatment is directed at relieving the pruritus associated with polymorphic eruption of pregnancy (PEP). Topical corticosteroids are the mainstay of treatment.  High-potency topical (class I or II), or even systemic, steroids may be required to alleviate symptoms. Oral antihistamines are only mildly effective.
General treatment measures include the use of cool, soothing baths; emollients; wet soaks; and light cotton clothing. PEP tends to resolve spontaneously shortly after delivery. Morbidity is not increased for the fetus born to an affected mother. An older case report described early cesarean delivery to relieve a severe case of PEP.
For patients who strive to avoid the use of any medications when pregnant or breastfeeding, PEP has been successfully treated with intramuscular injection of autologous whole blood in three cases. 
The healthcare provider responsible for the patient's obstetric care should be made aware of the diagnosis, treatment, and favorable prognosis of PEP.
As previously mentioned, topical corticosteroids are the mainstay of treatment for polymorphic eruption of pregnancy (PEP).  Symptom alleviation may require high-potency topical (class I or II) steroids, such as fluocinonide, or even systemic steroids. Oral antihistamines are only mildly effective.
可以用 VENA 來舒緩症狀，讓病患晚上好睡覺
Diphenhydramine, an antihistamine, has a sedative effect that may help patients to sleep better; it is also an effective agent against pruritus resulting from histamine release during inflammatory reactions.
Medications may need to be used into the postpartum period. Pay attention to potential adverse effects with breastfeeding.
Corticosteroids have anti-inflammatory properties and cause profound and varied metabolic effects. In addition, these agents modify the body's immune response to diverse stimuli. Use systemic steroids for severe, refractory cases only.
Fluocinonide is a class II, high-potency, topical corticosteroid that inhibits cell proliferation. It is immunosuppressive and anti-inflammatory.
Fluticasone is a high-potency, topical corticosteroid that inhibits cell proliferation. It is immunosuppressive and anti-inflammatory.
Prednisone may decrease inflammation by reversing increased capillary permeability and suppressing polymorphonuclear leukocyte activity.
Antihistamines, 1st Generation
Antihistamines have a sedative effect that may improve sleep.
Diphenhydramine is used for the symptomatic relief of pruritus caused by the release of histamine in inflammatory reactions.
Hydroxyzine antagonizes H1 receptors in the periphery. It may suppress histamine activity and subsequently cause relieve of pruritus.
(1) the risk of asthma exacerbations associated with pregnancy can be reduced and lung function (FEV1) improved with the use of inhaled corticosteroid therapy;
(2) no studies Quick Reference to date, including studies of large birth registries, have related inhaled corticosteroid use to any increases in congenital malformations or other adverse perinatal outcomes; and (3) the preponderance of data on inhaled corticosteroids during pregnancy is with budesonide. Few or no studies are available on the other inhaled corticosteroid formulations during pregnancy.
1. 可以使用 BETA-AGONIST
2. 可以使用 口服類固醇
3. 可以使用 Anticholinergics, 但應該與 BETA-AGONIST 併用, 且不該放在第一線用藥